Biosis Healing SIS biomaterials research results included in SCI core journals again

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At the end of 2021, Biosis Healing SIS biomaterials research delivers another success.

Composites Part B, an international high-impact journal in the field of composite materials, titled "Asymmetric SIS Membranes Specifically Loaded with Exosomes through the Modification of Engineered Recombinant Peptides for Guide Bone Regeneration", published the full text in Biosis Healing's independent intellectual property research results in the field of SIS biomaterials.

The journal has an impact factor of 9.229, and is currently the Double Winners journal of impact factor and article acceptance in the field of composite materials.

This research was completed by the team of Prof. Zhao Bo and Dr. Wei Pengfei from Biosis Healing, the team of Prof. Deng Jiayin and Dr. Liu Zihao from School and Hospital of Stomatology Tianjin Medical University, and the team of Dr. Ma Shiqing from the Second Hospital of Tianjin Medical University. The main research object is SIS biomaterials with independent intellectual property rights of Biosis Healing.

Biosis Healing SIS biomaterial is an excellent extracellular matrix material, which is widely used in skin, angiocarpy, abdominal wall, cartilage defects and other damaged tissues repair due to its low immunogenicity, excellent mechanical properties and tissue regeneration ability, and the repair effect is remarkable.

Guided Bone Regeneration (GBR) technology is one of the most commonly used methods for repairing bone defects. Barrier membranes play a crucial role in the application of GBR technology, eliminating interference from non-osteogenic tissues during bone healing, and at the same time for Bone regeneration provides a favorable environment.

Picture: Schematic diagram of the preparation of SIS-P1P2-EXO membranes for guided bone regeneration

In this study, the researchers modified the SIS material membrane by introducing preparation technology, developed an asymmetric SIS membrane using a liquid nitrogen quencher, and modified the SIS membrane with exosomes through peptides.

Subsequently, a series of in vivo and in vitro experiments demonstrated that asymmetric SIS membranes modified with peptides and exosomes could effectively reconstruct bone defects within 12 weeks. It provides a detailed theoretical basis for SIS membrane as a promising GBR membrane for repairing bone defects.

Picture: Histological and immunohistochemical analysis of newly formed bone at 12 weeks

【Journal introduction】

"Composites Part B" is Elsevier's 30-year-old journal. It is currently the ranks No.1 journal in the field of composite materials, with an impact factor (9.229) and article acceptance (more than 1,000 articles per year). The journal focuses on fiber-reinforced resin matrix composites. There has also been a dramatic increase in journal attention and article acceptance for biological materials in recent years.

【Introduction of author】

Zhao Bo

  Biosis Healing founder, doctor of surgery

  Professor-level senior engineer/ associate chief physician/ graduate supervisor/postdoctoral supervisor

As the main completion and project leader, he has undertaken and completed four projects of National Natural Science Foundation of China, Beijing Natural Science Foundation and many scientific research projects.

Deng Jiayin

Doctor of Stomatology, Professor, Doctoral Supervisor

Deputy Secretary of the Party Committee and Deputy Dean of School and Hospital of Stomatology Tianjin Medical University

Member of the Standing Committee of the Professional Committee of Stomatology Education of the Chinese Stomatology Association, Member of the Standing Committee of the Stomatology Branch of the Chinese Medical Doctor Association,

Member of the Standing Committee of the Professional Committee of Stomatology Education of the Chinese Stomatology Association, Member of the Standing Committee of the Stomatology Branch of the Chinese Medical Doctor Association, Member of the Periodontology Specialty Committee of the Chinese Stomatology Association, Standing Director of the Tianjin Stomatology Association, Vice chairman of the Periodontology Specialty Committee of the Tianjin Stomatology Association, Academician of the International College of Dentists.

2 second prizes of Tianjin Science and Technology Progress Award, 1 first prize and 1 second prize of Tianjin Teaching Achievement Award, and 2 new medical and health technology blank projects in Tianjin.

Liu Zihao

Doctor of Stomatology, Attending Doctor, Lecturer

Youth committee of the Professional Committee of Stomatology Education of the Chinese Stomatology Association

131 Third-level Talents in Tianjin

Award Tianjin Education Commission fund, Health Commission fund

Award The second prize of Tianjin Scientific and Technological Progress in 2020

Ma Shiqing

Department of Stomatology, Second Hospital of Tianjin Medical University, Lecturer, Attending Doctor

Young committee of the Professional Committee of General Oral of the Chinese Stomatological Association

Research direction is guided tissue regeneration and implant surface modification

Presided over 1 youth project of the National Natural Science Foundation of China

In the past 5 years, he has published 5 SCI papers as the first author and 1 SCI paper as the corresponding author, with a cumulative impact factor of 58.46

Won the second prize of Tianjin Science and Technology Progress Award

131 Third-level Talents in Tianjin

Candidates for the "Young Reserve Talents Support Program" in Tianjin Universities

Outstanding Teacher of Tianjin Medical University

Wei Pengfei

Beijing Biosis Healing Biotechnology Co., Ltd. Post-doctoral

Doctor of Biomedical Materials, Beijing University of Chemical Technology

He was supported by the 68th batch of China Postdoctoral Science Foundation

2020 Annual Postdoctoral International Exchange Program Academic Exchange Project

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