Two papers on SIS hydrogel published in the SCI core journals

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The news of 6 papers on SCI core journals in 2021 is still fresh, here comes another big news for Biosis Healing in the beginning of 2022.

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Picture: The research result of Biosis Healing SIS hydrogel included in the authoritative SCI core journal "Materials Today Bio", with an impact factor of 7.348

Recently, two papers on the latest research results of Biosis Healing SIS hydrogels have been included in the full text of the international top journal "Materials Today Bio" in the field of materials and "Cell Proliferation", a Q1 journal of cell biology, with impact factors of 7.348 and 6.831 respectively.

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Picture: The research result of Biosis Healing SIS hydrogel included in the authoritative SCI core journal "Cell Proliferation", with an impact factor of 6.831

This two studies are completed by the team of Prof. Zhao Bo, Dr. Wei Pengfei and Dr. Jing Wei from Biosis Healing, the team of Prof. Deng Jiayin and Dr. Liu Zihao from School and Hospital of Stomatology Tianjin Medical University, and the team of Dr. Ma Shiqing from the Second Hospital of Tianjin Medical University.

SIS biomaterials are derived from animal small intestinal submucosa, mainly natural ECM, including type I, type III collagen and various biologically active factors. Collagen molecules in SIS can self-assemble and condense into three-dimensional (3D) network hydrogels under 37℃, namely SIS hydrogels. Because the structure and bioactivity of SIS hydrogels can be fine-tuned for desired applications, they are widely used to promote regeneration of damaged tissues.

This two studies are based on the advantages of SIS hydrogels, aiming at the pain points and difficulties in the field of clinical bone repair and diabetic foot wound healing, and exploring their potential applications, providing a reliable theoretical basis for the clinical application of SIS hydrogels in this field.

Title: Novel fusion peptides deliver exosomes to modify injectable thermo-sensitive hydrogels for bone regeneration

Journal: Materials Today Bio

Impact Factor: 7.348

Introduction:

Bone defects are often caused by trauma, infection, tumors, congenital diseases, and can lead to functional impairments derived from skeletal disease. Compared with bone grafting, bone tissue engineering techniques have been considered as a potential treatment for bone reconstruction. Thermosensitive hydrogels can mimic the extracellular matrix (ECM) environment and can be widely used as scaffolds for bone tissue engineering.

Injectable thermosensitive hydrogels composed of small intestinal submucosa (SIS) and exosomes derived from bone marrow mesenchymal stem cells (BMSC) can be used for bone regeneration.

In this study, SIS hydrogel was added to exosomes and fusion peptides, and in vitro experiments showed that fusion peptides helped to promote the positive effect of exosomes on the osteogenic differentiation of BMSCs. At the same time, the results of hydrogels combined with exosomes and fusion peptides in the treatment of rat calvarial defect models showed that fusion peptides could increase the remaining amount and stability of exosomes, thereby enhancing the therapeutic effect on calvarial defects.

Therefore, the study proves that SIS hydrogels with CA modified by fusion peptides and exosomes can be applied in bone regenerative medicine.

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Picture: Osteogenic differentiation of BMSCs

Title: Functional Extracellular Matrix Hydrogel Modified with MSCs-Derived Small Extracellular Vesicles for Chronic Wound Healing

Journal: Cell Proliferation

Impact Factor: 6.831

Introduction:

Diabetic wound healing remains a major clinical and research challenge globally, and this issue is even more urgent as the number of diabetic patients increases year by year.

Chronic wounds in diabetic take a long time to heal due to the lack of a range of specific molecular and cellular processes in the healing process. Appropriate microenvironment and supplementation of growth factors can improve the local microenvironment in patients with diabetic ulcers and promote skin regeneration and functional recovery.

In this study, we combined peptides with SIS hydrogel materials (SC-Ps-sEVs) to increase the content and achieve sustained release by utilizing small extracellular vesicles (sEVs). NIH3T3 cells were used to evaluate the biocompatibility and ability to promote proliferation, migration and adhesion of SC-Ps-sEVs. EA.hy926 cells were used to evaluate SC-Ps-sEVs ability of stimulated angiogenesis. A diabetic wound model was used to study the functional role of SC-Ps-sEVs hydrogels in promoting wound healing.

Studies have shown that SIS hydrogels modified with small extracellular vesicles and polypeptides have good mechanical properties, good biocompatibility, and strong stimulating angiogenesis ability, which can effectively achieve full-thickness skin wound healing in a diabetic rat model.

The modified SIS hydrogel wound dressings have broad application in the field of regenerative medicine and can similarly be used to treat wounds in epithelial tissues such as the intestine, lung and liver.

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Pictured: Healing process and histological evaluation of SC-Ps-sEVs hydrogel dressing for diabetic wound treatment

【Introduction of author】

Zhao Bo

Biosis Healing founder, doctor of surgery

Professor-level senior engineer/ associate chief physician/ graduate supervisor/ postdoctoral supervisor

As the main completion and project leader, he has undertaken and completed four projects of National Natural Science Foundation of China,Beijing Natural Science Foundation and many scientific research projects.

Deng Jiayin

Doctor of Stomatology, Professor, Doctoral Supervisor

Deputy Secretary of the Party Committee and Deputy Dean of School and Hospital of Stomatology Tianjin Medical University

Member of the Standing Committee of the Professional Committee of Stomatology Education of the Chinese Stomatology Association, Member of the Standing Committee of the Stomatology Branch of the Chinese Medical Doctor Association, Member of the Periodontology Specialty Committee of the Chinese Stomatology Association, Standing Director of the Tianjin Stomatology Association, Vice chairman of the Periodontology Specialty Committee of the Tianjin Stomatology Association, Academician of the International College of Dentists

2 second prizes of Tianjin Science and Technology Progress Award, 1 first prize and 1 second prize of Tianjin Teaching Achievement Award, and 2 new medical and health technology blank projects in Tianjin.

Liu Zihao

Doctor of Stomatology, Attending Doctor, Lecturer

Youth committee of the Professional Committee of Stomatology Education of the Chinese Stomatology Association

131 Third-level Talents in Tianjin

Award Tianjin Education Commission fund, Health Commission fund

Award The second prize of Tianjin Scientific and Technological Progress in 2020

Ma Shiqing

Department of Stomatology, Second Hospital of Tianjin Medical University, Lecturer, Attending Doctor

Young committee of the Professional Committee of General Oral of the Chinese Stomatological Association

Research direction is guided tissue regeneration and implant surface modification

Presided over 1 youth project of the National Natural Science Foundation of China

In the past 5 years, he has published 5 SCI papers as the first author and 1 SCI paper as the corresponding author, with a cumulative impact factor of 58.46

Won the second prize of Tianjin Science and Technology Progress Award 131 Third-level Talents in Tianjin

Candidates for the "Young Reserve Talents Support Program" in Tianjin Universities

Outstanding Teacher of Tianjin Medical University

Wei Pengfei

Beijing Biosis Healing Biotechnology Co., Ltd. Post-doctoral

Doctor of Biomedical Materials, Beijing University of Chemical Technology

Supported by the 68th batch of China Postdoctoral Science Foundation

2020 Annual Postdoctoral International Exchange Program Academic Exchange Project

Jing Wei

Beijing Biosis Healing Biotechnology Co., Ltd. Post-doctoral

Doctor of Biomedical Materials, Beijing University of Chemical Technology

Supported by the 66th batch of China Postdoctoral Science Foundation

2020 Annual Postdoctoral International Exchange Program Academic Exchange Project

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